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==Crystal structure of imaginal disc growth factor-2==
==Crystal structure of imaginal disc growth factor-2==
<StructureSection load='1jnd' size='340' side='right' caption='[[1jnd]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='1jnd' size='340' side='right'caption='[[1jnd]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jnd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JND OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JND FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JND FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnd OCA], [http://pdbe.org/1jnd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jnd RCSB], [http://www.ebi.ac.uk/pdbsum/1jnd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnd ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnd OCA], [https://pdbe.org/1jnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnd RCSB], [https://www.ebi.ac.uk/pdbsum/1jnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDGF2_DROME IDGF2_DROME] Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.<ref>PMID:9847235</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnd_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnd_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Llera, A S]]
[[Category: Large Structures]]
[[Category: Mariuzza, R A]]
[[Category: Llera AS]]
[[Category: Tormo, J]]
[[Category: Mariuzza RA]]
[[Category: Varela, P F]]
[[Category: Tormo J]]
[[Category: Chitinase]]
[[Category: Varela PF]]
[[Category: Growth factor]]
[[Category: Heparin]]
[[Category: Hormone-growth factor complex]]
[[Category: Idgf]]
[[Category: Imaginal disc]]
[[Category: Insulin receptor]]
Retrieved from "https://proteopedia.org/1jnd"