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==human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor==
==human cationic trypsin G193R mutant in complex with bovine pancreatic trypsin inhibitor==
<StructureSection load='4wwy' size='340' side='right' caption='[[4wwy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4wwy' size='340' side='right'caption='[[4wwy]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wwy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WWY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wwy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WWY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wxv|4wxv]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wwy OCA], [https://pdbe.org/4wwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wwy RCSB], [https://www.ebi.ac.uk/pdbsum/4wwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wwy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wwy OCA], [http://pdbe.org/4wwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wwy RCSB], [http://www.ebi.ac.uk/pdbsum/4wwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wwy ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[http://omim.org/entry/167800 167800]]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref> <ref>PMID:8841182</ref> <ref>PMID:11866271</ref> <ref>PMID:9322498</ref> <ref>PMID:9633818</ref> <ref>PMID:10381903</ref> <ref>PMID:10204851</ref> <ref>PMID:11073545</ref> <ref>PMID:11788572</ref> <ref>PMID:14695529</ref> <ref>PMID:15776435</ref>
[https://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN] Defects in PRSS1 are a cause of pancreatitis (PCTT) [MIM:[https://omim.org/entry/167800 167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks.<ref>PMID:10930381</ref> <ref>PMID:8841182</ref> <ref>PMID:11866271</ref> <ref>PMID:9322498</ref> <ref>PMID:9633818</ref> <ref>PMID:10381903</ref> <ref>PMID:10204851</ref> <ref>PMID:11073545</ref> <ref>PMID:11788572</ref> <ref>PMID:14695529</ref> <ref>PMID:15776435</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN]] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref> [[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
[https://www.uniprot.org/uniprot/TRY1_HUMAN TRY1_HUMAN] Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.<ref>PMID:7945238</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Basic Pancreatic Trypsin Inhibitor|Basic Pancreatic Trypsin Inhibitor]]
*[[BPTI 3D structures|BPTI 3D structures]]
*[[Trypsin 3D structures|Trypsin 3D structures]]
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Trypsin]]
[[Category: Bos taurus]]
[[Category: Alloy, A]]
[[Category: Homo sapiens]]
[[Category: Kayode, O]]
[[Category: Large Structures]]
[[Category: Radisky, E S]]
[[Category: Alloy A]]
[[Category: Soares, A S]]
[[Category: Kayode O]]
[[Category: Wang, R]]
[[Category: Radisky ES]]
[[Category: Bpti]]
[[Category: Soares AS]]
[[Category: Complex]]
[[Category: Wang R]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Trypsin inhibitor]]
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