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==Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator==
==Crystal structure of E. coli threonyl-tRNA synthetase interacting with the essential domain of its mRNA operator==
<StructureSection load='1kog' size='340' side='right' caption='[[1kog]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='1kog' size='340' side='right'caption='[[1kog]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kog]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KOG FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kog]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KOG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TSB:5-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE'>TSB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1evl|1evl]], [[1qf6|1qf6]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TSB:5-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE'>TSB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Threonine--tRNA_ligase Threonine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.3 6.1.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kog OCA], [https://pdbe.org/1kog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kog RCSB], [https://www.ebi.ac.uk/pdbsum/1kog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kog ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kog OCA], [http://pdbe.org/1kog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kog RCSB], [http://www.ebi.ac.uk/pdbsum/1kog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kog ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI]] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]  
[https://www.uniprot.org/uniprot/SYT_ECOLI SYT_ECOLI] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA.[HAMAP-Rule:MF_00184]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1kog_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/1kog_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1kog" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1kog" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Threonine--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Caillet, J]]
[[Category: Caillet J]]
[[Category: Dock-Bregeon, A C]]
[[Category: Dock-Bregeon AC]]
[[Category: Ehresmann, B]]
[[Category: Ehresmann B]]
[[Category: Ehresmann, C]]
[[Category: Ehresmann C]]
[[Category: Moras, D]]
[[Category: Moras D]]
[[Category: Rees, B]]
[[Category: Rees B]]
[[Category: Romby, P]]
[[Category: Romby P]]
[[Category: Sankaranarayanan, R]]
[[Category: Sankaranarayanan R]]
[[Category: Springer, M]]
[[Category: Springer M]]
[[Category: Torres-Larrios, A]]
[[Category: Torres-Larrios A]]
[[Category: Ligase-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Rna base triple]]
[[Category: Rna double helix]]
[[Category: Rna stem-loop]]
Retrieved from "https://proteopedia.org/1kog"