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==Crystal structure of the core fragment of MutY from E.coli at 1.2A resolution==
==Crystal structure of the core fragment of MutY from E.coli at 1.2A resolution==
<StructureSection load='1kg2' size='340' side='right' caption='[[1kg2]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='1kg2' size='340' side='right'caption='[[1kg2]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kg2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KG2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kg2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KG2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kg3|1kg3]], [[1kg4|1kg4]], [[1kg5|1kg5]], [[1kg6|1kg6]], [[1kg7|1kg7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mutY ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg2 OCA], [https://pdbe.org/1kg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kg2 RCSB], [https://www.ebi.ac.uk/pdbsum/1kg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kg2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kg2 OCA], [http://pdbe.org/1kg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kg2 RCSB], [http://www.ebi.ac.uk/pdbsum/1kg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kg2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MUTY_ECOLI MUTY_ECOLI]] Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).  
[https://www.uniprot.org/uniprot/MUTY_ECOLI MUTY_ECOLI] Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg2_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/1kg2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[DNA glycosylase|DNA glycosylase]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Gerchman, S E]]
[[Category: Large Structures]]
[[Category: Gilboa, R]]
[[Category: Gerchman SE]]
[[Category: Grollman, A P]]
[[Category: Gilboa R]]
[[Category: Kilshtein, A]]
[[Category: Grollman AP]]
[[Category: Kycia, J H]]
[[Category: Kilshtein A]]
[[Category: Shoham, G]]
[[Category: Kycia JH]]
[[Category: Zharkov, D O]]
[[Category: Shoham G]]
[[Category: Dna repair]]
[[Category: Zharkov DO]]
[[Category: Hydrolase]]

Latest revision as of 06:23, 13 August 2026

Crystal structure of the core fragment of MutY from E.coli at 1.2A resolution

1kg2, resolution 1.20Å

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