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==CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR==
==CRYSTAL STRUCTURE OF TICK ANTICOAGULANT PROTEIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR==
<StructureSection load='1d0d' size='340' side='right' caption='[[1d0d]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='1d0d' size='340' side='right'caption='[[1d0d]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1d0d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Argasid_tick Argasid tick] and [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D0D FirstGlance]. <br>
<table><tr><td colspan='2'>[[1d0d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D0D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d0d OCA], [http://pdbe.org/1d0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d0d RCSB], [http://www.ebi.ac.uk/pdbsum/1d0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d0d ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d0d OCA], [https://pdbe.org/1d0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d0d RCSB], [https://www.ebi.ac.uk/pdbsum/1d0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d0d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TAP_ORNMO TAP_ORNMO]] TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa. [[http://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN]] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.  
[https://www.uniprot.org/uniprot/TAP_ORNMO TAP_ORNMO] TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/1d0d_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/1d0d_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 1d0d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1d0d" style="background-color:#fffaf0;"></div>
==See Also==
*[[BPTI 3D structures|BPTI 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Argasid tick]]
[[Category: Bos taurus]]
[[Category: Bovin]]
[[Category: Large Structures]]
[[Category: Arni, R V]]
[[Category: Ornithodoros moubata]]
[[Category: Padmanabhan, K]]
[[Category: Arni RV]]
[[Category: Padmanabhan, K P]]
[[Category: Padmanabhan K]]
[[Category: St Charles, R]]
[[Category: Padmanabhan KP]]
[[Category: Tulinsky, A]]
[[Category: StCharles R]]
[[Category: Blood clotting inhibitor]]
[[Category: Tulinsky A]]
[[Category: Factor xa inhibitor]]
[[Category: Kunitz inhibitor]]
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