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==Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.2110.4==
==Receptor binding domain of BoNT/B in complex with mini-protein binder Bot.2110.4==
<StructureSection load='5vmr' size='340' side='right' caption='[[5vmr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5vmr' size='340' side='right'caption='[[5vmr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vmr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VMR FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vmr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VMR FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmr OCA], [http://pdbe.org/5vmr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vmr RCSB], [http://www.ebi.ac.uk/pdbsum/5vmr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vmr OCA], [https://pdbe.org/5vmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vmr RCSB], [https://www.ebi.ac.uk/pdbsum/5vmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vmr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.  
[https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5vmr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5vmr" style="background-color:#fffaf0;"></div>
==See Also==
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Jin, R]]
[[Category: Large Structures]]
[[Category: Lam, K]]
[[Category: Unidentified]]
[[Category: Yao, G]]
[[Category: Jin R]]
[[Category: Inhibitor]]
[[Category: Lam K]]
[[Category: Mini-protein binder]]
[[Category: Yao G]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/5vmr"