5h5p: Difference between revisions

<StructureSection load='5h5p' size='340' side='right'caption='[[5h5p]], [[Resolution|resolution]] 2.46&Aring;' scene=''>

<table><tr><td colspan='2'>[[5h5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H5P FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.461&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5p OCA], [https://pdbe.org/5h5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h5p RCSB], [https://www.ebi.ac.uk/pdbsum/5h5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5p ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MYRF_MOUSE MYRF_MOUSE] Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.<ref>PMID:23966833</ref>  Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.<ref>PMID:23966833</ref>  Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833).<ref>PMID:19596243</ref> <ref>PMID:22956843</ref> <ref>PMID:23966833</ref> <ref>PMID:24204311</ref> <ref>PMID:27532821</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Li B]]

[[Category: Shi N]]

[[Category: Zhen X]]