2hui: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid== | ==Crystal structure of Aedes aegypti alanine glyoxylate aminotransferase in complex with glyoxylic acid== | ||
<StructureSection load='2hui' size='340' side='right' caption='[[2hui]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='2hui' size='340' side='right'caption='[[2hui]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hui]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2hui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aedes_aegypti Aedes aegypti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLV:GLYOXYLIC+ACID'>GLV</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hui OCA], [https://pdbe.org/2hui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hui RCSB], [https://www.ebi.ac.uk/pdbsum/2hui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hui ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/AGT_AEDAE AGT_AEDAE] Catalyzes the pyridoxal 5'-phosphate-dependent transamination of alanine with glyoxylate as an amino group acceptor (PubMed:16681462). Can also catalyze, although with much less efficiency, the transamination of serine, and histidine with glyoxylate and the and transamination of glycine with pyruvate as an amino group acceptor (PubMed:16681462). Does not catalyze the transamination of both 3-hydroxykynurenine and L-kynurenine (PubMed:16681462). May play a role in the detoxification of glyoxylate, a toxic plant metabolite from the pupae and adult diet (Probable).<ref>PMID:16681462</ref> <ref>PMID:16681462</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hui_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hui_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 31: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Aminotransferase|Aminotransferase]] | *[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aedes aegypti]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Gao | [[Category: Gao YG]] | ||
[[Category: Han | [[Category: Han Q]] | ||
[[Category: Li | [[Category: Li J]] | ||
[[Category: Rizzi | [[Category: Rizzi M]] | ||
[[Category: Robinson | [[Category: Robinson H]] | ||
[[Category: Vogelaar | [[Category: Vogelaar N]] | ||
[[Category: Wilson | [[Category: Wilson SR]] | ||
