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==Crystal structure of Human Choline Kinase B==
==Crystal structure of Human Choline Kinase B==
<StructureSection load='2ig7' size='340' side='right' caption='[[2ig7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2ig7' size='340' side='right'caption='[[2ig7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ig7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IG7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ig7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IG7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHKB, CHETK, CHKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ig7 OCA], [https://pdbe.org/2ig7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ig7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ig7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ig7 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Choline_kinase Choline kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.32 2.7.1.32] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ig7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ig7 OCA], [http://pdbe.org/2ig7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ig7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ig7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ig7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CHKB_HUMAN CHKB_HUMAN]] Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.<ref>PMID:19915674</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2ig7_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2ig7_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ig7 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ig7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
 
<references/>
==See Also==
*[[Choline kinase 3D structures|Choline kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Choline kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Landry, R]]
[[Category: Landry R]]
[[Category: Nedyalkova, L]]
[[Category: Nedyalkova L]]
[[Category: Park, H]]
[[Category: Park H]]
[[Category: Rabeh, W M]]
[[Category: Rabeh WM]]
[[Category: Structural genomic]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M]]
[[Category: Tempel W]]
[[Category: Tempel, W]]
[[Category: Vedadi M]]
[[Category: Vedadi, M]]
[[Category: Wasney G]]
[[Category: Wasney, G]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Non-protein kinase]]
[[Category: Sgc]]
[[Category: Transferase]]

Latest revision as of 01:03, 21 November 2024

Crystal structure of Human Choline Kinase B

2ig7, resolution 1.80Å

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