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==Arabidopsis thaliana IspD in complex with Isoxazole (4)==
==Arabidopsis thaliana IspD in complex with Isoxazole (4)==
<StructureSection load='5mrm' size='340' side='right' caption='[[5mrm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='5mrm' size='340' side='right'caption='[[5mrm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mrm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MRM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mrm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MRM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=Q9T:2,4-bis(bromanyl)-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol'>Q9T</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[4nak|4nak]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=Q9T:2,4-bis(bromanyl)-6-[3-(trifluoromethyl)-1,2-oxazol-5-yl]phenol'>Q9T</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrm OCA], [https://pdbe.org/5mrm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mrm RCSB], [https://www.ebi.ac.uk/pdbsum/5mrm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mrm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mrm OCA], [http://pdbe.org/5mrm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mrm RCSB], [http://www.ebi.ac.uk/pdbsum/5mrm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mrm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISPD_ARATH ISPD_ARATH]] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.<ref>PMID:10841550</ref> <ref>PMID:12029484</ref> <ref>PMID:18236010</ref>
[https://www.uniprot.org/uniprot/ISPD_ARATH ISPD_ARATH] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.<ref>PMID:10841550</ref> <ref>PMID:12029484</ref> <ref>PMID:18236010</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mrm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mrm" style="background-color:#fffaf0;"></div>
==See Also==
*[[MEP cytidylyltransferase 3D structures|MEP cytidylyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]]
[[Category: Arabidopsis thaliana]]
[[Category: Bacher, A]]
[[Category: Large Structures]]
[[Category: Diederich, F]]
[[Category: Bacher A]]
[[Category: Fischer, M]]
[[Category: Diederich F]]
[[Category: Frank, A]]
[[Category: Fischer M]]
[[Category: Groll, M]]
[[Category: Frank A]]
[[Category: Illarionov, B]]
[[Category: Groll M]]
[[Category: Kunfermann, A]]
[[Category: Illarionov B]]
[[Category: Schwab, A]]
[[Category: Kunfermann A]]
[[Category: Seet, M]]
[[Category: Schwab A]]
[[Category: Witschel, M]]
[[Category: Seet M]]
[[Category: Allosteric inhibition]]
[[Category: Witschel M]]
[[Category: Anti-infective]]
[[Category: Drug discovery]]
[[Category: Herbicide]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/5mrm"