Metallothiol transferase FosB: Difference between revisions
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==INTRODUCTION== | ==INTRODUCTION== | ||
The '''transcription factor''', DeltaFosB, is known to be involved in some of the physiological mechanisms linked to addiction and compulsive behaviors. Levels of DeltaFosB have been shown to increase in multiple regions of the brain in response to repeated drug exposure as well as stress, certain antipsychotic or antidepressant medications, electroconvulsive seizures, and certain lesions. DeltaFosB is a truncated, highly stable splice variant of the FosB transcription factor whose expression is regulated by alternative splicing of the FosB gene. Due to this splicing, DeltaFosB is known to have a half life five times that of FosB, which is thought to be a basis for addiction <ref name ="James">PMID:25083822</ref>. | The '''transcription factor''', '''DeltaFosB''', is known to be involved in some of the physiological mechanisms linked to addiction and compulsive behaviors. Levels of DeltaFosB have been shown to increase in multiple regions of the brain in response to repeated drug exposure as well as stress, certain antipsychotic or antidepressant medications, electroconvulsive seizures, and certain lesions. DeltaFosB is a truncated, highly stable splice variant of the FosB transcription factor whose expression is regulated by alternative splicing of the FosB gene. Due to this splicing, DeltaFosB is known to have a half life five times that of FosB, which is thought to be a basis for addiction <ref name ="James">PMID:25083822</ref>. | ||
==STRUCTURE== | ==STRUCTURE== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[6uci]], [[6ucl]], [[6ucm]] – hFosB Bzip domain 153-219 - human<br /> | |||
[[5vpa]], [[5vpb]], [[5vpc]], [[5vpd]] – hFosB Bzip domain + Jun-D<br /> | |||
[[5vpe]], [[5vpf]] – hFosB Bzip domain + Jun-D + DNA<br /> | |||
[[4ir0]], [[4jd1]], [[5f6q]] – FosB2 – ''Bacillus anthracis''<br /> | [[4ir0]], [[4jd1]], [[5f6q]] – FosB2 – ''Bacillus anthracis''<br /> | ||
[[4nay]], [[4naz]], [[4nb2]] – SaFosB – ''Staphylococcus aureus''<br /> | [[4nay]], [[4naz]], [[4nb2]] – SaFosB – ''Staphylococcus aureus''<br /> | ||
[[4jh1]], [[4jh2]] – BcFosB – ''Bacillus cereu''s<br /> | [[4jh1]], [[4jh2]], [[8g7i]] – BcFosB – ''Bacillus cereu''s<br /> | ||
[[4jh3]], [[4jh4]], [[4jh5]], [[4jh6]] – BcFosB + fosfomycin<br /> | [[4jh3]], [[4jh4]], [[4jh5]], [[4jh6]] – BcFosB + fosfomycin<br /> | ||
[[4jh7]], [[4jh8]], [[4jh9]] – BcFosB + fosfomycin derivative<br /> | [[4jh7]], [[4jh8]], [[4jh9]] – BcFosB + fosfomycin derivative<br /> | ||
[[8dtd]], [[8e7q]], [[8e7r]], [[8g7f]], [[8g7g]], [[8g7h]] – BcFosB + phosphonic acid derivative<br /> | |||
[[4nb0]], [[4nb1]] – SaFosB + cysteine<br /> | [[4nb0]], [[4nb1]] – SaFosB + cysteine<br /> | ||
[[7n7g]] – FosB + fosfomycin – ''Enterococcus faecium''<br /> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
