PCSK9: Difference between revisions

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== Function ==

'''PCSK9''' or '''Proprotein Convertase Subtilisin/Kexin type 9''' is a proteinase which is part of the cholesterol synthesis<ref>PMID:17502100</ref>. PCSK9 undergoes autocatalysis producing an active enzyme from its precursor. PCSK9 binds to EGF-A domain of the LDL receptor (LDLR) inducing its degradation.

'''PCSK9''' or '''Proprotein Convertase Subtilisin/Kexin type 9''' is a proteinase which is part of the cholesterol synthesis<ref>PMID:17502100</ref>. PCSK9 undergoes autocatalysis producing an active enzyme from its precursor. PCSK9 binds to EGF-A domain of the LDL receptor (LDLR) inducing its degradation. See details in [[Pro-protein convertase subtilisin/kexin type 9 (PCSK9)]].

== Relevance ==

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== Structural highlights ==

*<scene name='55/553967/Cv/4'>PCSK9 catalytic domain interactions with LDL receptor EGF-A domain</scene>. Water molecules are shown as red spheres.

*<scene name='55/553967/Cv/7'>PCSK9 catalytic domain interactions with LDL receptor EGF-A domain</scene>. Water molecules are shown as red spheres.

*<scene name='55/553967/Cv/5'>PCSK9 Ca coordination site</scene>.

*<scene name='55/553967/Cv/8'>PCSK9 Ca coordination site</scene>.

*<scene name='55/553967/Cv/6'>LDL receptor Ca coordination site</scene>.

*<scene name='55/553967/Cv/9'>LDL receptor Ca coordination site</scene>.

</StructureSection>

==3D structures of PCSK9==

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[2p4e]], [[2pmw]], [[2qtw]] – hPCSK9 – human

[[2p4e]], [[2pmw]], [[2qtw]], [[8wfr]] – hPCSK9 – human

[[3bps]], [[2w2m]], [[3gcx]] – hPCSK9 + LDLR EGF-A

[[2w2n]], [[3gcw]] – hPCSK9 + LDLR EGF-A (mutant)

[[2w2o]], [[2w2p]], [[2w2q]] – hPCSK9 (mutant) + LDLR EGF-A

[[2w2o]], [[2w2p]], [[2w2q]], [[7kev]], [[7kfa]] – hPCSK9 (mutant) + LDLR EGF-A

[[2xtj]], [[3sqo]], [[4k8r]], [[5vl7]] – hPCSK9 + antibody

[[3h42]] – hPCSK9 (mutant) + antibody

[[~~2xtj~~]], [[~~3sqo~~]], [[~~4k8r~~]] – hPCSK9 + antibody

[[6u26]], [[6u2n]], [[6u2p]] – hPCSK9 + inhibitor

[[6u2f]], [[6u36]], [[6u38]], [[6u3i]], [[6u3x]] – hPCSK9 + antibody + inhibitor

[[4nmx]], [[5vla]], [[5vlh]], [[5vkl]], [[5vll]], [[6xib]], [[6xic]], [[6xid]], [[6xie]], [[6xif]], [[7s5h]], [[8fpk]], [[8fpq]], [[8fvl]], [[8fvm]], [[8fvn]], [[8fvo]], [[8fvp]], [[8fvq]], [[8vdv]] – hPCSK9 + peptide inhibitor

[[6e4y]], [[6e4z]], [[6mv5]] – hPCSK9 N terminal + antibody

[[7s5g]] – hPCSK9 + peptide + inhibitor

[[6u2f]], [[6u3i]] – hPCSK9 + antibody + peptide inhibitor

[[3m0c]] – hPCSK9 (mutant) + LDLR

[[3p5b]], [[3p5c]] – hPCSK9 + LDLR variant

[[4ov6]] – hPCSK9 + adnectin

[[7anq]] – hPCSK9 C terminal + VHH minibody

[[6olz]], [[6om0]], [[6om7]] – hPCSK9 in ribosome – Cryo EM

== References ==

[[Category:Topic Page]]

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@@ Line 1: / Line 1: @@
 <StructureSection load='' size='400' side='right' caption='Structure of human PCSK9 catalytic domain (blue) and prodomain (green) complex with LDL receptor EGF-A domain (magenta) and Ca+2 ion (PDB entry [[2w2m]])' scene='55/553967/Cv/2' pspeed='8'>
 == Function ==
-'''PCSK9''' or '''Proprotein Convertase Subtilisin/Kexin type 9''' is a proteinase which is part of the cholesterol synthesis<ref>PMID:17502100</ref>.  PCSK9 undergoes autocatalysis producing an active enzyme from its precursor.  PCSK9 binds to EGF-A domain of the LDL receptor (LDLR) inducing its degradation.
+'''PCSK9''' or '''Proprotein Convertase Subtilisin/Kexin type 9''' is a proteinase which is part of the cholesterol synthesis<ref>PMID:17502100</ref>.  PCSK9 undergoes autocatalysis producing an active enzyme from its precursor.  PCSK9 binds to EGF-A domain of the LDL receptor (LDLR) inducing its degradation.  See details in [[Pro-protein convertase subtilisin/kexin type 9 (PCSK9)]].
 == Relevance ==
@@ Line 7: / Line 7: @@
 == Structural highlights ==
-*<scene name='55/553967/Cv/4'>PCSK9 catalytic domain interactions with LDL receptor EGF-A domain</scene>. Water molecules are shown as red spheres.
+*<scene name='55/553967/Cv/7'>PCSK9 catalytic domain interactions with LDL receptor EGF-A domain</scene>. Water molecules are shown as red spheres.
-*<scene name='55/553967/Cv/5'>PCSK9 Ca coordination site</scene>.
+*<scene name='55/553967/Cv/8'>PCSK9 Ca coordination site</scene>.
-*<scene name='55/553967/Cv/6'>LDL receptor Ca coordination site</scene>.
+*<scene name='55/553967/Cv/9'>LDL receptor Ca coordination site</scene>.
 </StructureSection>
 ==3D structures of PCSK9==
@@ Line 15: / Line 15: @@
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[2p4e]], [[2pmw]], [[2qtw]] – hPCSK9 – human <br />
+[[2p4e]], [[2pmw]], [[2qtw]], [[8wfr]] – hPCSK9 – human <br />
 [[3bps]], [[2w2m]], [[3gcx]] – hPCSK9 + LDLR EGF-A <br />
 [[2w2n]], [[3gcw]] – hPCSK9 + LDLR EGF-A (mutant)<br />
-[[2w2o]], [[2w2p]], [[2w2q]] – hPCSK9 (mutant) + LDLR EGF-A <br />
+[[2w2o]], [[2w2p]], [[2w2q]], [[7kev]], [[7kfa]] – hPCSK9 (mutant) + LDLR EGF-A <br />
+[[2xtj]], [[3sqo]], [[4k8r]], [[5vl7]] – hPCSK9 + antibody <br />
 [[3h42]] – hPCSK9 (mutant) + antibody <br />
-[[2xtj]], [[3sqo]], [[4k8r]] – hPCSK9 + antibody <br />
+[[6u26]], [[6u2n]], [[6u2p]] – hPCSK9 + inhibitor<br />
+[[6u2f]], [[6u36]], [[6u38]], [[6u3i]], [[6u3x]] – hPCSK9 + antibody + inhibitor<br />
+[[4nmx]], [[5vla]], [[5vlh]], [[5vkl]], [[5vll]], [[6xib]], [[6xic]], [[6xid]], [[6xie]], [[6xif]], [[7s5h]], [[8fpk]], [[8fpq]], [[8fvl]], [[8fvm]], [[8fvn]], [[8fvo]], [[8fvp]], [[8fvq]], [[8vdv]]  – hPCSK9 + peptide inhibitor<br />
+[[6e4y]], [[6e4z]], [[6mv5]] – hPCSK9 N terminal + antibody <br />
+[[7s5g]] – hPCSK9 + peptide + inhibitor<br />
+[[6u2f]], [[6u3i]] – hPCSK9 + antibody + peptide inhibitor<br />
 [[3m0c]] – hPCSK9 (mutant) + LDLR <br />
 [[3p5b]], [[3p5c]] – hPCSK9 + LDLR variant <br />
 [[4ov6]] – hPCSK9 + adnectin <br />
+[[7anq]] – hPCSK9 C terminal + VHH minibody <br />
+[[6olz]], [[6om0]], [[6om7]] – hPCSK9 in ribosome – Cryo EM <br />
 == References ==
 <references/>
 [[Category:Topic Page]]