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[[Image:1zgr.gif|left|200px]]


{{Structure
==Crystal structure of the Parkia platycephala seed lectin==
|PDB= 1zgr |SIZE=350|CAPTION= <scene name='initialview01'>1zgr</scene>, resolution 2.50&Aring;
<StructureSection load='1zgr' size='340' side='right'caption='[[1zgr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1zgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZGR FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgr OCA], [https://pdbe.org/1zgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zgr RCSB], [https://www.ebi.ac.uk/pdbsum/1zgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zgr ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[1zgs|1ZGS]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zgr OCA], [http://www.ebi.ac.uk/pdbsum/1zgr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zgr RCSB]</span>
[https://www.uniprot.org/uniprot/LEC_PARPC LEC_PARPC] Mannose/glucose specific lectin. Shows agglutinating activity against rabbit erythrocytes.<ref>PMID:11502201</ref>
}}
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
'''Crystal structure of the Parkia platycephala seed lectin'''
Check<jmol>
 
  <jmolCheckbox>
 
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zg/1zgr_consurf.spt"</scriptWhenChecked>
==Overview==
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
The crystal structures of the apo and mannose-bound Parkia platycephala seed lectin represent the first structure of a Mimosoideae lectin and a novel circular arrangement of beta-prism domains, and highlight the adaptability of the beta-prism fold as a building block in the evolution of plant lectins. The P.platycephala lectin is a dimer both in solution and in the crystals. Mannose binding to each of the three homologous carbohydrate-recognition domains of the lectin occurs through different modes, and restrains the flexibility of surface-exposed loops and residues involved in carbohydrate recognition. The planar array of carbohydrate-binding sites on the rim of the toroid-shaped structure of the P.platycephala lectin dimer immediately suggests a mechanism to promote multivalent interactions leading to cross-linking of carbohydrate ligands as part of the host strategy against phytopredators and pathogens. The cyclic structure of the P.platycephala lectin points to the convergent evolution of a structural principle for the construction of lectins involved in host defense or in attacking other organisms.
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zgr ConSurf].
1ZGR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Parkia_platycephala Parkia platycephala]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZGR OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
The first crystal structure of a Mimosoideae lectin reveals a novel quaternary arrangement of a widespread domain., Gallego del Sol F, Nagano C, Cavada BS, Calvete JJ, J Mol Biol. 2005 Oct 28;353(3):574-83. Epub 2005 Sep 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16185708 16185708]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Parkia platycephala]]
[[Category: Parkia platycephala]]
[[Category: Single protein]]
[[Category: Calvete JJ]]
[[Category: Calvete, J J.]]
[[Category: Cavada BS]]
[[Category: Cavada, B S.]]
[[Category: Gallego del Sol F]]
[[Category: Sol, F Gallego del.]]
[[Category: beta-prism]]
[[Category: lectin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:36:01 2008''

Latest revision as of 13:39, 13 March 2024

Crystal structure of the Parkia platycephala seed lectin

1zgr, resolution 2.50Å

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