5yhf: Difference between revisions

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'''Unreleased structure'''


The entry 5yhf is ON HOLD until Paper Publication
==Crystal structure of SecDF in Super-membrane-facing form==
<StructureSection load='5yhf' size='340' side='right'caption='[[5yhf]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5yhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YHF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yhf OCA], [https://pdbe.org/5yhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yhf RCSB], [https://www.ebi.ac.uk/pdbsum/5yhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yhf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SECDF_THET8 SECDF_THET8] Conducts protons, which can be regulated by a proton gradient or by binding of an unfolded protein. Proton conduction requires the large periplasmic domain of the SecD.[HAMAP-Rule:MF_01463_B] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.[HAMAP-Rule:MF_01463_B]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The membrane protein SecDF, belonging to the RND superfamily, enhances protein translocation at the extracytoplasmic side using a proton gradient. Here, we report the crystal structure of SecDF in a form we named Super-membrane-facing (Super F) form, demonstrating a beta-barrel architecture instead of the previously reported beta-sheet structure. Through this structural insight and supporting results of an in vivo crosslinking experiment, we propose a remote coupling model in which a structural change of the transmembrane region drives a functional, extracytoplasmic conformational transition.


Authors: Tanaka, Y., Tsukazaki, T., Yoshikaie, K., Furukawa, A.
Remote Coupled Drastic beta-Barrel to beta-Sheet Transition of the Protein Translocation Motor.,Furukawa A, Nakayama S, Yoshikaie K, Tanaka Y, Tsukazaki T Structure. 2018 Jan 26. pii: S0969-2126(18)30002-9. doi:, 10.1016/j.str.2018.01.002. PMID:29398525<ref>PMID:29398525</ref>


Description: Crystal structure of a Sec translocon"" to ""Crystal structure of a Sec translocon comportnet
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Yoshikaie, K]]
<div class="pdbe-citations 5yhf" style="background-color:#fffaf0;"></div>
[[Category: Tsukazaki, T]]
== References ==
[[Category: Furukawa, A]]
<references/>
[[Category: Tanaka, Y]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Furukawa A]]
[[Category: Tanaka Y]]
[[Category: Tsukazaki T]]
[[Category: Yoshikaie K]]
Retrieved from "https://proteopedia.org/5yhf"