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==Crystal structure of Ctf19-Mcm21 kinetochore assembly bound with Ctf19-Mcm21 binding motif of central kinetochore subunit Okp1==
==Crystal structure of Ctf19-Mcm21 kinetochore assembly bound with Ctf19-Mcm21 binding motif of central kinetochore subunit Okp1==
<StructureSection load='5mu3' size='340' side='right' caption='[[5mu3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5mu3' size='340' side='right'caption='[[5mu3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mu3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MU3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mu3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Kluyveromyces_lactis_NRRL_Y-1140 Kluyveromyces lactis NRRL Y-1140]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU3 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zxu|3zxu]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu3 OCA], [http://pdbe.org/5mu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mu3 RCSB], [http://www.ebi.ac.uk/pdbsum/5mu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu3 OCA], [https://pdbe.org/5mu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu3 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CTF19_KLULA CTF19_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity). [[http://www.uniprot.org/uniprot/MCM21_KLULA MCM21_KLULA]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation (By similarity).  
[https://www.uniprot.org/uniprot/CENPO_KLULA CENPO_KLULA] Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis (By similarity). Component of the inner kinetochore COMA subcomplex, which connects centromere-associated proteins and the outer kinetochore (PubMed:29046335). COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity).[UniProtKB:Q06675]<ref>PMID:29046335</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Schmitzberger, F]]
[[Category: Kluyveromyces lactis NRRL Y-1140]]
[[Category: Cell cycle]]
[[Category: Large Structures]]
[[Category: Centromere]]
[[Category: Schmitzberger F]]
[[Category: Chromosome segregation]]
[[Category: Kinetochore]]
[[Category: Rwd domain]]
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