5wiu: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Structure of the human D4 Dopamine receptor in complex with Nemonapride== | ==Structure of the human D4 Dopamine receptor in complex with Nemonapride== | ||
<StructureSection load='5wiu' size='340' side='right' caption='[[5wiu]], [[Resolution|resolution]] 1.96Å' scene=''> | <StructureSection load='5wiu' size='340' side='right'caption='[[5wiu]], [[Resolution|resolution]] 1.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5wiu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WIU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQD: | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.962Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AQD:5-chloranyl-2-methoxy-4-(methylamino)-~{N}-[(2~{R},3~{R})-2-methyl-1-(phenylmethyl)pyrrolidin-3-yl]benzamide'>AQD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wiu OCA], [https://pdbe.org/5wiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wiu RCSB], [https://www.ebi.ac.uk/pdbsum/5wiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wiu ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DRD4_HUMAN DRD4_HUMAN] Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 5wiu" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5wiu" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Dopamine receptor 3D structures|Dopamine receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Betz | [[Category: Homo sapiens]] | ||
[[Category: Che | [[Category: Large Structures]] | ||
[[Category: Dror | [[Category: Betz RM]] | ||
[[Category: Huang | [[Category: Che T]] | ||
[[Category: Levit | [[Category: Dror RO]] | ||
[[Category: McCorvy | [[Category: Huang X-P]] | ||
[[Category: Roth | [[Category: Levit A]] | ||
[[Category: Shoichet | [[Category: McCorvy JD]] | ||
[[Category: Venkatakrishnan | [[Category: Roth BL]] | ||
[[Category: Wacker | [[Category: Shoichet BK]] | ||
[[Category: Wang | [[Category: Venkatakrishnan AJ]] | ||
[[Category: Wacker D]] | |||
[[Category: Wang S]] | |||
Latest revision as of 09:33, 23 October 2024
Structure of the human D4 Dopamine receptor in complex with Nemonapride
| ||||||||||||
