5ufi: Difference between revisions

<StructureSection load='5ufi' size='340' side='right' caption='[[5ufi]], [[Resolution|resolution]] 2.58&Aring;' scene=''>

<table><tr><td colspan='2'>[[5ufi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UFI FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8B1:N-[(1S)-1-cyclohexyl-2-{[3-(morpholin-4-yl)propanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide'>8B1</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ufi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ufi OCA], [http://pdbe.org/5ufi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ufi RCSB], [http://www.ebi.ac.uk/pdbsum/5ufi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ufi ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/DCNL1_HUMAN DCNL1_HUMAN]] Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).  

[[Category: Stuckey, J]]

[[Category: Complex]]

[[Category: E3 ligase]]

[[Category: Ligase-inhibitor complex]]