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[[Image:1zrh.gif|left|200px]]


{{Structure
==Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP==
|PDB= 1zrh |SIZE=350|CAPTION= <scene name='initialview01'>1zrh</scene>, resolution 2.10&Aring;
<StructureSection load='1zrh' size='340' side='right'caption='[[1zrh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
<table><tr><td colspan='2'>[[1zrh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZRH FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Heparan_sulfate]-glucosamine_3-sulfotransferase_1 [Heparan sulfate]-glucosamine 3-sulfotransferase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.23 2.8.2.23] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= HS3ST1, 3OST, 3OST1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [https://pdbe.org/1zrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB], [https://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zrh ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zrh OCA], [http://www.ebi.ac.uk/pdbsum/1zrh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zrh RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/HS3S1_HUMAN HS3S1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.<ref>PMID:9346953</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zr/1zrh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zrh ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP'''
==See Also==
 
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
1ZRH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZRH OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: [Heparan sulfate]-glucosamine 3-sulfotransferase 1]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Dombrovski L]]
[[Category: Dombrovski, L.]]
[[Category: Dong A]]
[[Category: Dong, A.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Loppnau P]]
[[Category: Loppnau, P.]]
[[Category: Plotnikov AN]]
[[Category: Plotnikov, A N.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom, M.]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: sulfotransferase hs3st1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:39 2008''

Latest revision as of 07:46, 30 October 2024

Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex with PAP

1zrh, resolution 2.10Å

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