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==Crystal structure of E. coli HPPK(H115A) in complex with AMPCPP and HP==
==Crystal structure of E. coli HPPK(H115A) in complex with AMPCPP and HP==
<StructureSection load='3kuh' size='340' side='right' caption='[[3kuh]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='3kuh' size='340' side='right'caption='[[3kuh]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3kuh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KUH FirstGlance]. <br>
<table><tr><td colspan='2'>[[3kuh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KUH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kue|3kue]], [[3kug|3kug]], [[1q0n|1q0n]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0142, foIK, folK, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuh OCA], [https://pdbe.org/3kuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kuh RCSB], [https://www.ebi.ac.uk/pdbsum/3kuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuh ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kuh OCA], [http://pdbe.org/3kuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kuh RCSB], [http://www.ebi.ac.uk/pdbsum/3kuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kuh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPPK_ECOLI HPPK_ECOLI]
==See Also==
*[[HPPK 3D structures|HPPK 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
[[Category: Escherichia coli K-12]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Blaszczyk, J]]
[[Category: Blaszczyk J]]
[[Category: Ji, X]]
[[Category: Ji X]]
[[Category: Li, Y]]
[[Category: Li Y]]
[[Category: Yan, H]]
[[Category: Yan H]]
[[Category: Alpha beta]]
[[Category: Atp-binding]]
[[Category: Folate biosynthesis]]
[[Category: Kinase]]
[[Category: Nucleotide-binding]]
[[Category: Transferase]]

Latest revision as of 06:35, 19 July 2023

Crystal structure of E. coli HPPK(H115A) in complex with AMPCPP and HP

3kuh, resolution 1.35Å

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