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==Crystal Structure of Glycogen Phosphorylase DK5 complex==
==Crystal Structure of Glycogen Phosphorylase DK5 complex==
<StructureSection load='3l7d' size='340' side='right' caption='[[3l7d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3l7d' size='340' side='right'caption='[[3l7d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l7d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L7D FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L7D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DK5:1-(2,3-DIDEOXY-3-FLUORO-BETA-D-ARABINO-HEXOPYRANOSYL)-4-[(PHENYLCARBONYL)AMINO]PYRIMIDIN-2(1H)-ONE'>DK5</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DK5:1-(2,3-DIDEOXY-3-FLUORO-BETA-D-ARABINO-HEXOPYRANOSYL)-4-[(PHENYLCARBONYL)AMINO]PYRIMIDIN-2(1H)-ONE'>DK5</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l79|3l79]], [[3l7a|3l7a]], [[3l7b|3l7b]], [[3l7c|3l7c]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7d OCA], [https://pdbe.org/3l7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l7d RCSB], [https://www.ebi.ac.uk/pdbsum/3l7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7d ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphorylase Phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.1 2.4.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l7d OCA], [http://pdbe.org/3l7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l7d RCSB], [http://www.ebi.ac.uk/pdbsum/3l7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l7d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT]] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.  
[https://www.uniprot.org/uniprot/PYGM_RABIT PYGM_RABIT] Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3l7d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3l7d" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glycogen phosphorylase 3D structures|Glycogen phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Phosphorylase]]
[[Category: Drakou C]]
[[Category: Drakou, C]]
[[Category: Hayes JM]]
[[Category: Hayes, J M]]
[[Category: Lamprakis C]]
[[Category: Lamprakis, C]]
[[Category: Leonidas DD]]
[[Category: Leonidas, D D]]
[[Category: Skamnaki V]]
[[Category: Skamnaki, V]]
[[Category: Tsirkone VG]]
[[Category: Tsirkone, V G]]
[[Category: Zographos SE]]
[[Category: Zographos, S E]]
[[Category: Allosteric enzyme]]
[[Category: Carbohydrate metabolism]]
[[Category: Glycogen metabolism]]
[[Category: Glycogenolysis]]
[[Category: Glycosyltransferase]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Pyridoxal phosphate]]
[[Category: Transferase]]
[[Category: Type 2 diabetes]]
Retrieved from "https://proteopedia.org/3l7d"