1zu4: Difference between revisions

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[[Image:1zu4.gif|left|200px]]


{{Structure
==Crystal structure of FtsY from Mycoplasma mycoides- space group P21212==
|PDB= 1zu4 |SIZE=350|CAPTION= <scene name='initialview01'>1zu4</scene>, resolution 1.95&Aring;
<StructureSection load='1zu4' size='340' side='right'caption='[[1zu4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[1zu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_mycoides Mycoplasma mycoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZU4 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zu4 OCA], [https://pdbe.org/1zu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zu4 RCSB], [https://www.ebi.ac.uk/pdbsum/1zu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zu4 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1zu5|1ZU5]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zu4 OCA], [http://www.ebi.ac.uk/pdbsum/1zu4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zu4 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/FTSY_MYCMS FTSY_MYCMS] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).[HAMAP-Rule:MF_00920]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zu/1zu4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zu4 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The prokaryotic signal recognition particle Ffh and its receptor FtsY allow targeting of proteins into or across the plasma membrane. The targeting process is GTP dependent and the two proteins constitute a distinct GTPase family. The receptor FtsY is composed of A and NG domains where the NG's GTPase domain plays a critical role in the targeting process. In this study, we describe two X-ray structures determined independently of each other of the NG domain of FtsY from Mycoplasma mycoides (MmFtsY). The two structures are markedly different in three of the nucleotide-binding segments, GI (P-loop), GII, and GIII, making only one of the structures compatible with nucleotide binding. Interestingly, the two distinct conformations of the nucleotide-binding segments of MmFtsY are similar to the apo- and ADP-loaded forms of certain ATPases. The structure of the extended interface between the A and NG domains of MmFtsY provides new insights into the role of the A domain for phospholipid interaction.


'''Crystal structure of FtsY from Mycoplasma mycoides- space group P21212'''
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY.,Gariani T, Samuelsson T, Sauer-Eriksson AE J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944<ref>PMID:16343944</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1zu4" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
The prokaryotic signal recognition particle Ffh and its receptor FtsY allow targeting of proteins into or across the plasma membrane. The targeting process is GTP dependent and the two proteins constitute a distinct GTPase family. The receptor FtsY is composed of A and NG domains where the NG's GTPase domain plays a critical role in the targeting process. In this study, we describe two X-ray structures determined independently of each other of the NG domain of FtsY from Mycoplasma mycoides (MmFtsY). The two structures are markedly different in three of the nucleotide-binding segments, GI (P-loop), GII, and GIII, making only one of the structures compatible with nucleotide binding. Interestingly, the two distinct conformations of the nucleotide-binding segments of MmFtsY are similar to the apo- and ADP-loaded forms of certain ATPases. The structure of the extended interface between the A and NG domains of MmFtsY provides new insights into the role of the A domain for phospholipid interaction.
*[[Signal recognition particle receptor|Signal recognition particle receptor]]
 
== References ==
==About this Structure==
<references/>
1ZU4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_mycoides Mycoplasma mycoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU4 OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY., Gariani T, Samuelsson T, Sauer-Eriksson AE, J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16343944 16343944]
[[Category: Mycoplasma mycoides]]
[[Category: Mycoplasma mycoides]]
[[Category: Single protein]]
[[Category: Gariani T]]
[[Category: Gariani, T.]]
[[Category: Samuelsson T]]
[[Category: Samuelsson, T.]]
[[Category: Sauer-Eriksson AE]]
[[Category: Sauer-Eriksson, A E.]]
[[Category: ftsy]]
[[Category: gtpase]]
[[Category: receptor]]
[[Category: signal recognition particle]]
[[Category: srp]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:41:41 2008''

Latest revision as of 08:15, 25 October 2023

Crystal structure of FtsY from Mycoplasma mycoides- space group P21212

1zu4, resolution 1.95Å

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