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==Crystal structure of the mouse C5a-desArg anaphylatoxin==
==Crystal structure of the mouse C5a-desArg anaphylatoxin==
<StructureSection load='4p3b' size='340' side='right' caption='[[4p3b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4p3b' size='340' side='right'caption='[[4p3b]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p3b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P3B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p3b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P3B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p3a|4p3a]], [[4p39|4p39]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C5, Hc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3b OCA], [https://pdbe.org/4p3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p3b RCSB], [https://www.ebi.ac.uk/pdbsum/4p3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p3b OCA], [http://pdbe.org/4p3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p3b RCSB], [http://www.ebi.ac.uk/pdbsum/4p3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p3b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CO5_MOUSE CO5_MOUSE]] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.  Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).  
[https://www.uniprot.org/uniprot/CO5_MOUSE CO5_MOUSE] Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.  Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4p3b" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4p3b" style="background-color:#fffaf0;"></div>
==See Also==
*[[Complement C5 3D structures|Complement C5 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Andersen, G R]]
[[Category: Mus musculus]]
[[Category: Schatz-Jakobsen, J A]]
[[Category: Andersen GR]]
[[Category: Yatime, L]]
[[Category: Schatz-Jakobsen JA]]
[[Category: C5a]]
[[Category: Yatime L]]
[[Category: Complement anaphylatoxin]]
[[Category: Four-helix bundle]]
[[Category: Gpcr agonist]]
[[Category: Immune system]]
Retrieved from "https://proteopedia.org/4p3b"