2vww: Difference between revisions
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==ephB4 kinase domain inhibitor complex== | ==ephB4 kinase domain inhibitor complex== | ||
<StructureSection load='2vww' size='340' side='right' caption='[[2vww]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2vww' size='340' side='right'caption='[[2vww]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vww]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWW OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2vww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VWW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7X2:N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5-+TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE'>7X2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vww OCA], [https://pdbe.org/2vww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vww RCSB], [https://www.ebi.ac.uk/pdbsum/2vww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vww ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/EPHB4_HUMAN EPHB4_HUMAN] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.<ref>PMID:12734395</ref> <ref>PMID:16424904</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vww_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vww_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 2vww" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2vww" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Barratt | [[Category: Large Structures]] | ||
[[Category: Brassington | [[Category: Barratt D]] | ||
[[Category: Green | [[Category: Brassington CA]] | ||
[[Category: Kettle | [[Category: Green I]] | ||
[[Category: Leach | [[Category: Kettle JG]] | ||
[[Category: McCall | [[Category: Leach AG]] | ||
[[Category: Read | [[Category: McCall EJ]] | ||
[[Category: Valentine | [[Category: Read J]] | ||
[[Category: Valentine AL]] | |||
Latest revision as of 15:35, 13 December 2023
ephB4 kinase domain inhibitor complex
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