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==Crystal structure of mouse thiamine triphosphatase in complex with thiamine triphosphate.==
==Crystal structure of mouse thiamine triphosphatase in complex with thiamine triphosphate.==
<StructureSection load='5a64' size='340' side='right' caption='[[5a64]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='5a64' size='340' side='right'caption='[[5a64]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a64]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A64 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a64]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A64 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=V4E:THIAMINE+TRIPHOSPHATE'>V4E</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a5y|5a5y]], [[5a60|5a60]], [[5a61|5a61]], [[5a65|5a65]], [[5a66|5a66]], [[5a67|5a67]], [[5a68|5a68]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=V4E:THIAMINE+TRIPHOSPHATE'>V4E</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-triphosphatase Thiamine-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.28 3.6.1.28] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a64 OCA], [https://pdbe.org/5a64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a64 RCSB], [https://www.ebi.ac.uk/pdbsum/5a64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a64 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a64 OCA], [http://pdbe.org/5a64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a64 RCSB], [http://www.ebi.ac.uk/pdbsum/5a64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a64 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE]] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).  
[https://www.uniprot.org/uniprot/THTPA_MOUSE THTPA_MOUSE] Hydrolase highly specific for thiamine triphosphate (ThTP) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Thiamine-triphosphatase]]
[[Category: Mus musculus]]
[[Category: Hothorn, M]]
[[Category: Hothorn M]]
[[Category: Martinez, J]]
[[Category: Martinez J]]
[[Category: Truffault, V]]
[[Category: Truffault V]]
[[Category: Hydrolase]]
[[Category: Thiamine triphosphatase]]
[[Category: Triphosphate tunnel metalloenzyme]]
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