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==Crystal structure of GSDMA3==
==Crystal structure of GSDMA3==
<StructureSection load='5b5r' size='340' side='right' caption='[[5b5r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5b5r' size='340' side='right'caption='[[5b5r]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5b5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B5R FirstGlance]. <br>
<table><tr><td colspan='2'>[[5b5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B5R FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.902&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gsdma3, Gsdm3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5r OCA], [http://pdbe.org/5b5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b5r RCSB], [http://www.ebi.ac.uk/pdbsum/5b5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b5r OCA], [https://pdbe.org/5b5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b5r RCSB], [https://www.ebi.ac.uk/pdbsum/5b5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b5r ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE]] Defects in Gsdma3 are the cause of a number of alopecia phenotypes, bareskin (Bsk), defolliculated (Dfl), finnegan (Fgn) reduced coat 2 (Rco2), Rex-denuded (Re-den) and recombination induced mutation 3 (Rim3). These are dominant conditions characterized by loss of hair.<ref>PMID:15475261</ref> <ref>PMID:15737203</ref> <ref>PMID:17572385</ref>
[https://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE] Defects in Gsdma3 are the cause of a number of alopecia phenotypes, bareskin (Bsk), defolliculated (Dfl), finnegan (Fgn) reduced coat 2 (Rco2), Rex-denuded (Re-den) and recombination induced mutation 3 (Rim3). These are dominant conditions characterized by loss of hair.<ref>PMID:15475261</ref> <ref>PMID:15737203</ref> <ref>PMID:17572385</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE]] Upon activation, mediates pyroptosis (PubMed:26375003). May play a role in the transition from catagen to telogen at the end of hair follicle morphogenesis (PubMed:15475261).<ref>PMID:15475261</ref> <ref>PMID:26375003</ref>
[https://www.uniprot.org/uniprot/GSDA3_MOUSE GSDA3_MOUSE] Upon activation, mediates pyroptosis (PubMed:26375003). May play a role in the transition from catagen to telogen at the end of hair follicle morphogenesis (PubMed:15475261).<ref>PMID:15475261</ref> <ref>PMID:26375003</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5b5r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5b5r" style="background-color:#fffaf0;"></div>
==See Also==
*[[Gasdermin 3D structures|Gasdermin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Ding, J]]
[[Category: Mus musculus]]
[[Category: Shao, F]]
[[Category: Ding J]]
[[Category: Pyroptosis excutioner]]
[[Category: Shao F]]
[[Category: Transport protein]]
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