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==1-deoxy-D-xylulose 5-phosphate reductoisomerase from Yersinia pestis in complex with NADPH==
==1-deoxy-D-xylulose 5-phosphate reductoisomerase from Yersinia pestis in complex with NADPH==
<StructureSection load='5dul' size='340' side='right' caption='[[5dul]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5dul' size='340' side='right'caption='[[5dul]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dul]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DUL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DUL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iie|3iie]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dxr, YPO1048, y3131, YP_2802 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 "Bacillus pestis" (Lehmann and Neumann 1896) Migula 1900])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dul OCA], [https://pdbe.org/5dul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dul RCSB], [https://www.ebi.ac.uk/pdbsum/5dul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dul ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dul OCA], [http://pdbe.org/5dul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dul RCSB], [http://www.ebi.ac.uk/pdbsum/5dul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dul ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DXR_YERPE DXR_YERPE]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]  
[https://www.uniprot.org/uniprot/DXR_YERPE DXR_YERPE] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
 
==See Also==
*[[DXP reductoisomerase 3D Structures|DXP reductoisomerase 3D Structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
[[Category: Large Structures]]
[[Category: Anderson, W F]]
[[Category: Yersinia pestis]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Mulligan, R]]
[[Category: Mulligan R]]
[[Category: Osipiuk, J]]
[[Category: Osipiuk J]]
[[Category: Stam, J]]
[[Category: Stam J]]
[[Category: Csgid]]
[[Category: Idp00499]]
[[Category: Oxidoreductase]]
[[Category: Reductoisomerase]]
[[Category: Xylulose]]

Latest revision as of 22:00, 28 June 2023

1-deoxy-D-xylulose 5-phosphate reductoisomerase from Yersinia pestis in complex with NADPH

5dul, resolution 2.60Å

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