5hdt: Difference between revisions

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==Human cohesin regulator Pds5B bound to a Wapl peptide==
==Human cohesin regulator Pds5B bound to a Wapl peptide==
<StructureSection load='5hdt' size='340' side='right' caption='[[5hdt]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='5hdt' size='340' side='right'caption='[[5hdt]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5hdt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HDT FirstGlance]. <br>
<table><tr><td colspan='2'>[[5hdt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HDT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.711&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDS5B, APRIN, AS3, KIAA0979 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hdt OCA], [https://pdbe.org/5hdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hdt RCSB], [https://www.ebi.ac.uk/pdbsum/5hdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hdt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hdt OCA], [http://pdbe.org/5hdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hdt RCSB], [http://www.ebi.ac.uk/pdbsum/5hdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hdt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDS5B_HUMAN PDS5B_HUMAN]] Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.<ref>PMID:10963680</ref> <ref>PMID:15855230</ref> <ref>PMID:19696148</ref> [[http://www.uniprot.org/uniprot/WAPL_HUMAN WAPL_HUMAN]] Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.<ref>PMID:15150110</ref> <ref>PMID:17113138</ref> <ref>PMID:17112726</ref> <ref>PMID:19696148</ref> <ref>PMID:19907496</ref> <ref>PMID:21111234</ref> 
[https://www.uniprot.org/uniprot/PDS5B_HUMAN PDS5B_HUMAN] Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.<ref>PMID:10963680</ref> <ref>PMID:15855230</ref> <ref>PMID:19696148</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Ouyang, Z]]
[[Category: Large Structures]]
[[Category: Tomchick, D R]]
[[Category: Ouyang Z]]
[[Category: Yu, H]]
[[Category: Tomchick DR]]
[[Category: Cell cycle]]
[[Category: Yu H]]
[[Category: Cohesin regulator]]
[[Category: Ip6]]
[[Category: Pds5b]]
[[Category: Wapl]]
Retrieved from "https://proteopedia.org/5hdt"