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==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2==
==Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2==
<StructureSection load='5trg' size='340' side='right' caption='[[5trg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5trg' size='340' side='right'caption='[[5trg]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5trg]] is a 28 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TRG FirstGlance]. <br>
<table><tr><td colspan='2'>[[5trg]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TRG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7HJ:N,N-DIETHYL-N~2~-[(2E)-3-PHENYLPROP-2-ENOYL]-L-ASPARAGINYL-4-FLUORO-N-[(NAPHTHALEN-1-YL)METHYL]-L-PHENYLALANINAMIDE'>7HJ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.804&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5trr|5trr]], [[5trs|5trs]], [[5try|5try]], [[5ts0|5ts0]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7HJ:N,N-DIETHYL-N~2~-[(2E)-3-PHENYLPROP-2-ENOYL]-L-ASPARAGINYL-4-FLUORO-N-[(NAPHTHALEN-1-YL)METHYL]-L-PHENYLALANINAMIDE'>7HJ</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">prcA, MRA_2124 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), prcB, MRA_2125 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5trg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5trg OCA], [https://pdbe.org/5trg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5trg RCSB], [https://www.ebi.ac.uk/pdbsum/5trg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5trg ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5trg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5trg OCA], [http://pdbe.org/5trg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5trg RCSB], [http://www.ebi.ac.uk/pdbsum/5trg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5trg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.  
[https://www.uniprot.org/uniprot/PSA_MYCTU PSA_MYCTU] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave oligopeptides not only after hydrophobic but also after basic, acidic and small neutral residues. Among the identified substrates of the M.tuberculosis proteasome are the pupylated FabD, PanB and Mpa proteins. One function of the proteasome is to contribute to M.tuberculosis ability to resist killing by host macrophages, since the core proteasome is essential for persistence of the pathogen during the chronic phase of infection in mice. The mechanism of protection against bactericidal chemistries of the host's immune response probably involves the degradation of proteins that are irreversibly oxidized, nitrated, or nitrosated.<ref>PMID:16468985</ref> <ref>PMID:18059281</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5trg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5trg" style="background-color:#fffaf0;"></div>
==See Also==
*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Proteasome endopeptidase complex]]
[[Category: Large Structures]]
[[Category: Fan, H]]
[[Category: Hsu, H C]]
[[Category: Li, H]]
[[Category: Lin, G]]
[[Category: Nathan, C]]
[[Category: Singh, R K]]
[[Category: Sukenick, G]]
[[Category: Wang, R]]
[[Category: C-capped dipeptide]]
[[Category: Dplg-2]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Proteasome inhibitor]]
[[Category: Fan H]]
[[Category: Hsu H-C]]
[[Category: Li H]]
[[Category: Lin G]]
[[Category: Nathan C]]
[[Category: Singh RK]]
[[Category: Sukenick G]]
[[Category: Wang R]]
Retrieved from "https://proteopedia.org/5trg"