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==Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4==
==Cryo-EM structure of yeast cytoplasmic dynein with Walker B mutation at AAA3 in presence of ATP-VO4==
<StructureSection load='5vlj' size='340' side='right' caption='[[5vlj]], [[Resolution|resolution]] 10.50&Aring;' scene=''>
<SX load='5vlj' size='340' side='right' viewer='molstar' caption='[[5vlj]], [[Resolution|resolution]] 10.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vlj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VLJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vlj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VLJ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vh9|5vh9]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DYN1, DHC1, YKR054C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), PAC1, LIS1, SCY_5321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vlj OCA], [https://pdbe.org/5vlj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vlj RCSB], [https://www.ebi.ac.uk/pdbsum/5vlj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vlj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vlj OCA], [http://pdbe.org/5vlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vlj RCSB], [http://www.ebi.ac.uk/pdbsum/5vlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vlj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref> [[http://www.uniprot.org/uniprot/LIS1_YEAS7 LIS1_YEAS7]] Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
[https://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5vlj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5vlj" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Dynein 3D structures|Dynein 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Cianfrocco, M A]]
[[Category: Saccharomyces cerevisiae]]
[[Category: DeSantis, M E]]
[[Category: Cianfrocco MA]]
[[Category: Htet, Z M]]
[[Category: DeSantis ME]]
[[Category: Leschziner, A E]]
[[Category: Htet ZM]]
[[Category: Reck-Peterson, S L]]
[[Category: Leschziner AE]]
[[Category: Tran, P T]]
[[Category: Reck-Peterson SL]]
[[Category: Cytoplasmic dynein]]
[[Category: Tran PT]]
[[Category: Lis1]]
[[Category: Motor protein]]
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