5gvt: Difference between revisions
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==Crystal structures of the serine protease domain of murine plasma kallikrein== | |||
<StructureSection load='5gvt' size='340' side='right'caption='[[5gvt]], [[Resolution|resolution]] 2.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5gvt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GVT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gvt OCA], [https://pdbe.org/5gvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gvt RCSB], [https://www.ebi.ac.uk/pdbsum/5gvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gvt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KLKB1_MOUSE KLKB1_MOUSE] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. | |||
==See Also== | |||
*[[Kallikrein 3D structures|Kallikrein 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Huang | [[Category: Large Structures]] | ||
[[Category: Jiang | [[Category: Mus musculus]] | ||
[[Category: Xu | [[Category: Huang M]] | ||
[[Category: Jiang L]] | |||
[[Category: Xu M]] | |||
Latest revision as of 11:44, 2 August 2023
Crystal structures of the serine protease domain of murine plasma kallikrein
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