5yk5: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 5yk5 is ~~ON HOLD until Oct 12 2019~~

==structure of the human Lamtor4-Lamtor5 complex==

== Structural highlights ==

<table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YK5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [https://pdbe.org/5yk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [https://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>

~~Authors: Wu, G., Mu, Z.~~

==See Also==

*[[Ragulator complex 3D structures|Ragulator complex 3D structures]]

~~Description~~: ~~structure of the human Lamtor4-Lamtor5 complex~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Wu, G~~]]

__TOC__

[[Category: ~~Mu, Z~~]]

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Mu Z]]

[[Category: Wu G]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yk5 is ON HOLD  until Oct 12 2019
+==structure of the human Lamtor4-Lamtor5 complex==
+<StructureSection load='5yk5' size='340' side='right'caption='[[5yk5]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yk5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YK5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yk5 OCA], [https://pdbe.org/5yk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yk5 RCSB], [https://www.ebi.ac.uk/pdbsum/5yk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yk5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
-Authors: Wu, G., Mu, Z.
+==See Also==
+*[[Ragulator complex 3D structures|Ragulator complex 3D structures]]
-Description: structure of the human Lamtor4-Lamtor5 complex
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Wu, G]]
+__TOC__
-[[Category: Mu, Z]]
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mu Z]]
+[[Category: Wu G]]