3n2z: Difference between revisions

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==The Structure of Human Prolylcarboxypeptidase at 2.80 Angstroms Resolution==
==The Structure of Human Prolylcarboxypeptidase at 2.80 Angstroms Resolution==
<StructureSection load='3n2z' size='340' side='right' caption='[[3n2z]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='3n2z' size='340' side='right'caption='[[3n2z]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3n2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N2Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[3n2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N2Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jyh|3jyh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRCP, PCP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2z OCA], [https://pdbe.org/3n2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n2z RCSB], [https://www.ebi.ac.uk/pdbsum/3n2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n2z ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysosomal_Pro-Xaa_carboxypeptidase Lysosomal Pro-Xaa carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.2 3.4.16.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2z OCA], [http://pdbe.org/3n2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n2z RCSB], [http://www.ebi.ac.uk/pdbsum/3n2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n2z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PCP_HUMAN PCP_HUMAN]] Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.  
[https://www.uniprot.org/uniprot/PCP_HUMAN PCP_HUMAN] Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/3n2z_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n2/3n2z_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 3n2z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3n2z" style="background-color:#fffaf0;"></div>
==See Also==
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Lysosomal Pro-Xaa carboxypeptidase]]
[[Category: Large Structures]]
[[Category: Lumb, K J]]
[[Category: Lumb KJ]]
[[Category: Patel, S B]]
[[Category: Patel SB]]
[[Category: Sharma, S]]
[[Category: Sharma S]]
[[Category: Soisson, S M]]
[[Category: Soisson SM]]
[[Category: Alpha/beta hydrolase]]
[[Category: Hydrolase]]
[[Category: Prcp]]
[[Category: Serine carboxypeptidase]]
Retrieved from "https://proteopedia.org/3n2z"