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==Crystal structure of EBV gHgL/CL40/gp42 N-domain==
==Crystal structure of EBV gHgL/CL40/gp42 N-domain==
<StructureSection load='5w0k' size='340' side='right' caption='[[5w0k]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='5w0k' size='340' side='right'caption='[[5w0k]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5w0k]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvb9 Ebvb9] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W0K FirstGlance]. <br>
<table><tr><td colspan='2'>[[5w0k]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W0K FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gH, BXLF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10377 EBVB9]), gL, BKRF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10377 EBVB9])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w0k OCA], [http://pdbe.org/5w0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w0k RCSB], [http://www.ebi.ac.uk/pdbsum/5w0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w0k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w0k OCA], [https://pdbe.org/5w0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w0k RCSB], [https://www.ebi.ac.uk/pdbsum/5w0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w0k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GH_EBVB9 GH_EBVB9]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells.<ref>PMID:11021994</ref> [[http://www.uniprot.org/uniprot/GL_EBVB9 GL_EBVB9]] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells (By similarity). [[http://www.uniprot.org/uniprot/GP42_EBVB9 GP42_EBVB9]] Plays a role in virion attachment to host B-lymphocytes, through binding to leukocyte antigen (HLA) class II and subsequently participates in fusion of the virion with host membranes. May act as a tropism switch that directs fusion with B-lymphocytes and inhibits fusion with epithelial cells.<ref>PMID:12042810</ref> 
[https://www.uniprot.org/uniprot/GH_EBVB9 GH_EBVB9] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. Fusion of EBV with B-lymphocytes requires the additional receptor-binding protein gp42, which forms a complex with gH/gL. May also be required for virus attachment to epithelial cells.<ref>PMID:11021994</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ebvb9]]
[[Category: Human herpesvirus 4 strain B95-8]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Jardetzky, T S]]
[[Category: Mus musculus]]
[[Category: Sathiyamoorthy, K]]
[[Category: Jardetzky TS]]
[[Category: Epstein-barr virus]]
[[Category: Sathiyamoorthy K]]
[[Category: Herpesvirus entry]]
[[Category: Membrane fusion]]
[[Category: Receptor binding]]
[[Category: Viral protein]]
[[Category: Viral protein-immune system complex]]
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