5y7w: Difference between revisions

<StructureSection load='5y7w' size='340' side='right'caption='[[5y7w]], [[Resolution|resolution]] 2.25&Aring;' scene=''>

<table><tr><td colspan='2'>[[5y7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y7W FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALC:2-AMINO-3-CYCLOHEXYL-PROPIONIC+ACID'>ALC</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y7w OCA], [https://pdbe.org/5y7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y7w RCSB], [https://www.ebi.ac.uk/pdbsum/5y7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y7w ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NCOA1_MOUSE NCOA1_MOUSE] Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.<ref>PMID:8616895</ref> <ref>PMID:9506940</ref> <ref>PMID:12507421</ref> <ref>PMID:16148126</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Synthetic construct]]

[[Category: Bae JH]]

[[Category: Lee JH]]

[[Category: Lee YJ]]

[[Category: Lim HS]]

[[Category: Song JY]]

[[Category: Yoon HS]]