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[[Image:2afv.gif|left|200px]]


{{Structure
==The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis==
|PDB= 2afv |SIZE=350|CAPTION= <scene name='initialview01'>2afv</scene>, resolution 3.00&Aring;
<StructureSection load='2afv' size='340' side='right'caption='[[2afv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>
<table><tr><td colspan='2'>[[2afv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AFV FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Precorrin-8X_methylmutase Precorrin-8X methylmutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.1.2 5.4.1.2] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2afv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afv OCA], [https://pdbe.org/2afv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2afv RCSB], [https://www.ebi.ac.uk/pdbsum/2afv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2afv ProSAT]</span></td></tr>
|RELATEDENTRY=[[2afr|2AFR]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2afv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afv OCA], [http://www.ebi.ac.uk/pdbsum/2afv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2afv RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CBIC_LEPIN CBIC_LEPIN] Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate.
 
== Evolutionary Conservation ==
'''The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==Overview==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2afv_consurf.spt"</scriptWhenChecked>
The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2AFV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFV OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2afv ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis., Xue Y, Wei Z, Li X, Gong W, J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16427313 16427313]
</StructureSection>
[[Category: Large Structures]]
[[Category: Leptospira interrogans]]
[[Category: Leptospira interrogans]]
[[Category: Precorrin-8X methylmutase]]
[[Category: Wei Z]]
[[Category: Single protein]]
[[Category: Xue Y]]
[[Category: Wei, Z.]]
[[Category: Xue, Y.]]
[[Category: isomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:05 2008''

Latest revision as of 13:41, 13 March 2024

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

2afv, resolution 3.00Å

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