4fqs: Difference between revisions
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==Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed== | ==Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed== | ||
<StructureSection load='4fqs' size='340' side='right' caption='[[4fqs]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4fqs' size='340' side='right'caption='[[4fqs]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fqs]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FQS FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fqs OCA], [https://pdbe.org/4fqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fqs RCSB], [https://www.ebi.ac.uk/pdbsum/4fqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fqs ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/TYSY_MYCTU TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). | ||
==See Also== | |||
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Bruning | [[Category: Bruning JB]] | ||
[[Category: Harshbarger | [[Category: Harshbarger W]] | ||
[[Category: Reddy | [[Category: Reddy MCM]] | ||
[[Category: Sacchettini | [[Category: Sacchettini JC]] | ||
Latest revision as of 11:23, 1 March 2024
Crystal Structure of Mycobacterium tuberculosis ThyA in complex with UMP and Pemetrexed
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