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==1.7A structure of 5-Fluoro Tryptophan Labeled Protective Antigen (W206Y)==
==1.7A structure of 5-Fluoro Tryptophan Labeled Protective Antigen (W206Y)==
<StructureSection load='4nam' size='340' side='right' caption='[[4nam]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4nam' size='340' side='right'caption='[[4nam]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NAM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FTR:FLUOROTRYPTOPHANE'>FTR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FTR:FLUOROTRYPTOPHANE'>FTR</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pagA, pag, pXO1-110, BXA0164, GBAA_pXO1_0164 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nam OCA], [https://pdbe.org/4nam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nam RCSB], [https://www.ebi.ac.uk/pdbsum/4nam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nam ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nam OCA], [http://pdbe.org/4nam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nam RCSB], [http://www.ebi.ac.uk/pdbsum/4nam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nam ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN]] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.  
[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bann, J G]]
[[Category: Bacillus anthracis]]
[[Category: Battaile, K P]]
[[Category: Large Structures]]
[[Category: Chadegani, F]]
[[Category: Bann JG]]
[[Category: Lovell, S]]
[[Category: Battaile KP]]
[[Category: Miyagi, M]]
[[Category: Chadegani F]]
[[Category: Mulangi, V]]
[[Category: Lovell S]]
[[Category: 5-fluorotryptophan]]
[[Category: Miyagi M]]
[[Category: Anthrax]]
[[Category: Mulangi V]]
[[Category: Pore]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/4nam"