5lsn: Difference between revisions
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==SINEB2 element of the long non-coding RNA activator of translation AS Uchl1== | ==SINEB2 element of the long non-coding RNA activator of translation AS Uchl1== | ||
<StructureSection load='5lsn' size='340' side='right' caption='[[5lsn | <StructureSection load='5lsn' size='340' side='right'caption='[[5lsn]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5lsn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSN OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5lsn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LSN FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lsn OCA], [https://pdbe.org/5lsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lsn RCSB], [https://www.ebi.ac.uk/pdbsum/5lsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lsn ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Pervasive transcription of mammalian genomes leads to a previously underestimated level of complexity in gene regulatory networks. Recently, we have identified a new functional class of natural and synthetic antisense long non-coding RNAs (lncRNA) that increases translation of partially overlapping sense mRNAs. These molecules were named SINEUPs, as they require an embedded inverted SINE B2 element for their UP-regulation of translation. Mouse AS Uchl1 is the representative member of natural SINEUPs. It was originally discovered for its role in increasing translation of Uchl1 mRNA, a gene associated with neurodegenerative diseases. Here we present the secondary structure of the SINE B2 Transposable Element (TE) embedded in AS Uchl1. We find that specific structural regions, containing a short hairpin, are required for the ability of AS Uchl1 RNA to increase translation of its target mRNA. We also provide a high-resolution structure of the relevant hairpin, based on NMR observables. Our results highlight the importance of structural determinants in embedded TEs for their activity as functional domains in lncRNAs. | |||
Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1.,Podbevsek P, Fasolo F, Bon C, Cimatti L, Reisser S, Carninci P, Bussi G, Zucchelli S, Plavec J, Gustincich S Sci Rep. 2018 Feb 16;8(1):3189. doi: 10.1038/s41598-017-14908-6. PMID:29453387<ref>PMID:29453387</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5lsn" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Plavec J]] | ||
[[Category: | [[Category: Podbevsek P]] | ||
