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==Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis==
==Crystal structure of YwfH, NADPH dependent reductase involved in Bacilysin biosynthesis==
<StructureSection load='3u4d' size='340' side='right' caption='[[3u4d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3u4d' size='340' side='right'caption='[[3u4d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3u4d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U4D FirstGlance]. <br>
<table><tr><td colspan='2'>[[3u4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U4D FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u49|3u49]], [[3u4c|3u4c]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU37680, ipa-86r, ywfH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u4d OCA], [https://pdbe.org/3u4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u4d RCSB], [https://www.ebi.ac.uk/pdbsum/3u4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u4d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u4d OCA], [http://pdbe.org/3u4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u4d RCSB], [http://www.ebi.ac.uk/pdbsum/3u4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u4d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/YWFH_BACSU YWFH_BACSU]] Along with the bacABCDE operon is involved in bacilysin biosynthesis.  
[https://www.uniprot.org/uniprot/BACG_BACSU BACG_BACSU] Along with the bacABCDEF operon, BacG is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. Bacilysin is an irreversible inactivator of the glutaminase domain of glucosamine synthetase (PubMed:20052993). BacG catalyzes the stereoselective reduction of exocyclic-delta(3),delta(5)-dihydro-hydroxyphenylpyruvate (ex-H2HPP), adding a pro-S hydride equivalent to C4 position to yield tetrahydro-hydroxyphenylpyruvate (H4HPP) (PubMed:22765234, PubMed:23519407). Although the 3Z,7R-ex-H2HPP isomer is kinetically disfavored by BacB and produced in a smaller quantity than 3E,7R-ex-H2HPP, it is the preferred substrate for the conjugate reduction reaction of BacG (PubMed:22765234, PubMed:23519407).<ref>PMID:20052993</ref> <ref>PMID:22765234</ref> <ref>PMID:23519407</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Gopal, B]]
[[Category: Large Structures]]
[[Category: Rajavel, M]]
[[Category: Gopal B]]
[[Category: Bacilysin biosynthesis]]
[[Category: Rajavel M]]
[[Category: Nadph binding motif]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]
[[Category: Sdr superfamily]]
Retrieved from "https://proteopedia.org/3u4d"