Virion infectivity factor: Difference between revisions
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<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' caption='HIV-1 virion infectivity factor (deep sky blue) complex with human elongin-B (green) and elongin-C (pink) (PDB code [[2ma9]])' scene='75/750233/Cv/1'> | ||
== Function == | == Function == | ||
Virion infectivity factor (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/ | '''Virion infectivity factor''' (Vif) of HIV-1 is essential for efficient viral replication by binding to the a component of the innate immune system and triggering its polyubiquitination and rapid degradation thus preventing its entry into progeny virions<ref>PMID:15177194</ref>. <scene name='75/750233/Cv/4'>Interactions between HIV-1 virion infectivity factor and human elongin-B and elongin-C</scene>. | ||
For details see [[HIV and accessory proteins]] | For details see [[HIV and accessory proteins]] | ||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[4n9f]] – | [[4n9f]] – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – HIV-1<br /> | ||
[[2ma9]], [[3dcg]] – Vif + elongin-C + elongin-B – | [[8fvi]], [[8fvj]] – HIVVif + cullin-5 + elongin-C + elongin-B + CBF-beta – Cryo EM<br /> | ||
[[2ma9]], [[3dcg]] – HIVVif + elongin-C + elongin-B <br /> | |||
[[6nil]] – HIVVif + CBF-β + AF3 - Cryo EM<br /> | |||
[[8cx0]], [[8cx1]], [[8cx2]] – HIVVif + elongin-C + elongin-B + CBF-β + RNA – Cryo EM<br /> | |||
[[8e40]] – HIVVif + deoxycytidine deaminase + CBF-β + RNA – Cryo EM<br /> | |||
[[6p59]] – Vif + elongin-C + elongin-B + CBF-β – SIV-1<br /> | |||
[[7upn]] – Vif + elongin-C + elongin-B + PPIase A – Visna-Maedi virus – Cryo EM<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
