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==Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens.==
==Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re- engineering for a tissue-specific role in the vertebrate eye lens.==
<StructureSection load='2j9i' size='340' side='right' caption='[[2j9i]], [[Resolution|resolution]] 17.00&Aring;' scene=''>
<SX load='2j9i' size='340' side='right' viewer='molstar' caption='[[2j9i]], [[Resolution|resolution]] 17.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j9i]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J9I FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j9i]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J9I FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9i OCA], [http://pdbe.org/2j9i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j9i RCSB], [http://www.ebi.ac.uk/pdbsum/2j9i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j9i ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 17&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9i OCA], [https://pdbe.org/2j9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j9i RCSB], [https://www.ebi.ac.uk/pdbsum/2j9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j9i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LGSN_MOUSE LGSN_MOUSE] May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.<ref>PMID:18178558</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/2j9i_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/2j9i_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2j9i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2j9i" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]
*[[Lengsin|Lengsin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Bateman, O A]]
[[Category: Mus musculus]]
[[Category: Orlova, E V]]
[[Category: Bateman OA]]
[[Category: Slingsby, C]]
[[Category: Orlova EV]]
[[Category: Wang, L]]
[[Category: Slingsby C]]
[[Category: White, H E]]
[[Category: Wang L]]
[[Category: Wistow, G]]
[[Category: White HE]]
[[Category: Wyatt, K]]
[[Category: Wistow G]]
[[Category: Ligase]]
[[Category: Wyatt K]]
Retrieved from "https://proteopedia.org/2j9i"