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==Human choline kinase a1 in complex with compound 4-(dimethylamino)-1-{4-[4-(4-{[4-(pyrrolidin- 1-yl)pyridinium-1-yl]methyl}phenyl)butyl]benzyl}pyridinium (compound BR25)==
==Human choline kinase a1 in complex with compound 4-(dimethylamino)-1-{4-[4-(4-{[4-(pyrrolidin- 1-yl)pyridinium-1-yl]methyl}phenyl)butyl]benzyl}pyridinium (compound BR25)==
<StructureSection load='5fut' size='340' side='right' caption='[[5fut]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5fut' size='340' side='right'caption='[[5fut]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fut]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUT FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FUT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PQ7:4-(DIMETHYLAMINO)-1-{4-[4-(4-{[4-(PYRROLIDIN-1-YL)PYRIDINIUM-1-YL]METHYL}PHENYL)BUTYL]BENZYL}PYRIDINIUM'>PQ7</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fut OCA], [http://pdbe.org/5fut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fut RCSB], [http://www.ebi.ac.uk/pdbsum/5fut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fut ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PQ7:4-(DIMETHYLAMINO)-1-{4-[4-(4-{[4-(PYRROLIDIN-1-YL)PYRIDINIUM-1-YL]METHYL}PHENYL)BUTYL]BENZYL}PYRIDINIUM'>PQ7</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fut OCA], [https://pdbe.org/5fut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fut RCSB], [https://www.ebi.ac.uk/pdbsum/5fut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fut ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5fut" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5fut" style="background-color:#fffaf0;"></div>
==See Also==
*[[Choline kinase 3D structures|Choline kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Conejo-Garcia, A]]
[[Category: Large Structures]]
[[Category: Denton, H]]
[[Category: Conejo-Garcia A]]
[[Category: Entrena, A]]
[[Category: Denton H]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Entrena A]]
[[Category: Izquierdo, L]]
[[Category: Hurtado-Guerrero R]]
[[Category: Lopez-Gutierrez, B]]
[[Category: Izquierdo L]]
[[Category: Rubio-Ruiz, B]]
[[Category: Lopez-Gutierrez B]]
[[Category: Serran-Aguilera, L]]
[[Category: Rubio-Ruiz B]]
[[Category: Smith, T K]]
[[Category: Serran-Aguilera L]]
[[Category: Choline kinase]]
[[Category: Smith TK]]
[[Category: Inhibitor]]
[[Category: Phosphatidyletanolamine]]
[[Category: Transferase]]
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