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New page: ==2.0 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with Uridine-diphosphate-2(n-acetylglucosaminyl) ...
 
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==2.0 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with Uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2R)-2-(phosphonooxy)propanoic acid and Magnesium.==
==2.0 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with Uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2R)-2-(phosphonooxy)propanoic acid and Magnesium.==
<StructureSection load='5wi5' size='340' side='right' caption='[[5wi5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5wi5' size='340' side='right'caption='[[5wi5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5wi5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WI5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5wi5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WI5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0V5:(2R)-2-(PHOSPHONOOXY)PROPANOIC+ACID'>0V5</scene>, <scene name='pdbligand=EPU:URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL)+BUTYRIC+ACID'>EPU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">murA1, murA, SP_1966 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=170187 STRPN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0V5:(2R)-2-(PHOSPHONOOXY)PROPANOIC+ACID'>0V5</scene>, <scene name='pdbligand=EPU:URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL)+BUTYRIC+ACID'>EPU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine_1-carboxyvinyltransferase UDP-N-acetylglucosamine 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.7 2.5.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi5 OCA], [https://pdbe.org/5wi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wi5 RCSB], [https://www.ebi.ac.uk/pdbsum/5wi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wi5 OCA], [http://pdbe.org/5wi5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wi5 RCSB], [http://www.ebi.ac.uk/pdbsum/5wi5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wi5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MURA1_STRPN MURA1_STRPN]] Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.  
[https://www.uniprot.org/uniprot/MURA1_STRPN MURA1_STRPN] Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
 
==See Also==
*[[Enoylpyruvate transferase 3D structures|Enoylpyruvate transferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Strpn]]
[[Category: Large Structures]]
[[Category: UDP-N-acetylglucosamine 1-carboxyvinyltransferase]]
[[Category: Streptococcus pneumoniae TIGR4]]
[[Category: Anderson, W F]]
[[Category: Anderson WF]]
[[Category: Structural genomic]]
[[Category: Dubrovska I]]
[[Category: Dubrovska, I]]
[[Category: Grimshaw S]]
[[Category: Grimshaw, S]]
[[Category: Kiryukhina O]]
[[Category: Kiryukhina, O]]
[[Category: Kwon K]]
[[Category: Kwon, K]]
[[Category: Minasov G]]
[[Category: Minasov, G]]
[[Category: Shuvalova L]]
[[Category: Shuvalova, L]]
[[Category: Csgid]]
[[Category: Magnesium]]
[[Category: Transferase]]
[[Category: Udp-n-acetylglucosamine 1-carboxyvinyltransferase]]

Latest revision as of 14:13, 4 October 2023

2.0 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with Uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2R)-2-(phosphonooxy)propanoic acid and Magnesium.

5wi5, resolution 2.00Å

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