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==The poly-C9 component of the Complement Membrane Attack Complex==
==The poly-C9 component of the Complement Membrane Attack Complex==
<StructureSection load='5fmw' size='340' side='right' caption='[[5fmw]], [[Resolution|resolution]] 6.70&Aring;' scene=''>
<SX load='5fmw' size='340' side='right' viewer='molstar' caption='[[5fmw]], [[Resolution|resolution]] 6.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fmw]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FMW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fmw]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FMW FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fmw OCA], [http://pdbe.org/5fmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fmw RCSB], [http://www.ebi.ac.uk/pdbsum/5fmw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fmw ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fmw OCA], [https://pdbe.org/5fmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fmw RCSB], [https://www.ebi.ac.uk/pdbsum/5fmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fmw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN]] Age-related macular degeneration;Immunodeficiency due to a late component of complements deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN] Age-related macular degeneration;Immunodeficiency due to a late component of complements deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry.  Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.  
[https://www.uniprot.org/uniprot/CO9_HUMAN CO9_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Conroy, P J]]
[[Category: Large Structures]]
[[Category: Dudkina, N V]]
[[Category: Conroy PJ]]
[[Category: Dunstone, M A]]
[[Category: Dudkina NV]]
[[Category: Ekkel, S M]]
[[Category: Dunstone MA]]
[[Category: Elmlund, H]]
[[Category: Ekkel SM]]
[[Category: Goode, R J.A]]
[[Category: Elmlund H]]
[[Category: Kondos, S C]]
[[Category: Goode RJA]]
[[Category: Law, R H.P]]
[[Category: Kondos SC]]
[[Category: Lukoyanova, N]]
[[Category: Law RHP]]
[[Category: Ramm, G]]
[[Category: Lukoyanova N]]
[[Category: Reboul, C F]]
[[Category: Ramm G]]
[[Category: Saibil, H R]]
[[Category: Reboul CF]]
[[Category: Spicer, B A]]
[[Category: Saibil HR]]
[[Category: Whisstock, J C]]
[[Category: Spicer BA]]
[[Category: C9]]
[[Category: Whisstock JC]]
[[Category: Complement]]
[[Category: Macpf]]
[[Category: Pore-forming protein]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/5fmw"