4rv8: Difference between revisions
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==Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131== | ==Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131== | ||
<StructureSection load='4rv8' size='340' side='right' caption='[[4rv8]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='4rv8' size='340' side='right'caption='[[4rv8]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4rv8]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4rv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptosporidium_parvum Cryptosporidium parvum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RV8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I13:1-(2-{3-[(1E)-N-(2-AMINOETHOXY)ETHANIMIDOYL]PHENYL}PROPAN-2-YL)-3-(4-CHLORO-3-NITROPHENYL)UREA'>I13</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.053Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=I13:1-(2-{3-[(1E)-N-(2-AMINOETHOXY)ETHANIMIDOYL]PHENYL}PROPAN-2-YL)-3-(4-CHLORO-3-NITROPHENYL)UREA'>I13</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv8 OCA], [https://pdbe.org/4rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IMDH_CRYPV IMDH_CRYPV] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).<ref>PMID:15269207</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 4rv8" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4rv8" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Cryptosporidium parvum]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Anderson | [[Category: Anderson WF]] | ||
[[Category: Gu M]] | |||
[[Category: Gu | [[Category: Hedstrom L]] | ||
[[Category: Hedstrom | [[Category: Joachimiak A]] | ||
[[Category: Joachimiak | [[Category: Kavitha M]] | ||
[[Category: Kavitha | [[Category: Kim Y]] | ||
[[Category: Kim | [[Category: Makowska-Grzyska M]] | ||
[[Category: Makowska-Grzyska | |||
