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==Mouse IL-2 Bound to JES6-1 scFv Fragment==
==Mouse IL-2 Bound to JES6-1 scFv Fragment==
<StructureSection load='4yqx' size='340' side='right' caption='[[4yqx]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
<StructureSection load='4yqx' size='340' side='right'caption='[[4yqx]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yqx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yqx]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.826&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Il2, Il-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqx OCA], [http://pdbe.org/4yqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqx RCSB], [http://www.ebi.ac.uk/pdbsum/4yqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqx OCA], [https://pdbe.org/4yqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqx RCSB], [https://www.ebi.ac.uk/pdbsum/4yqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IL2_MOUSE IL2_MOUSE]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.  
[https://www.uniprot.org/uniprot/IL2_MOUSE IL2_MOUSE] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yqx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yqx" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of non-human antibody|3D structures of non-human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Garcia, K C]]
[[Category: Rattus norvegicus]]
[[Category: Jude, K M]]
[[Category: Garcia KC]]
[[Category: Luca, V C]]
[[Category: Jude KM]]
[[Category: Spangler, J B]]
[[Category: Luca VC]]
[[Category: Antibody]]
[[Category: Spangler JB]]
[[Category: Chemokine]]
[[Category: Complex]]
[[Category: Cytokine-immune system complex]]

Latest revision as of 08:04, 27 September 2023

Mouse IL-2 Bound to JES6-1 scFv Fragment

4yqx, resolution 2.83Å

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