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==GES-2 carbapenemase apo form==
==GES-2 carbapenemase apo form==
<StructureSection load='3ni9' size='340' side='right' caption='[[3ni9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3ni9' size='340' side='right'caption='[[3ni9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ni9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NI9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ni9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NI9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nia|3nia]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ni9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ni9 OCA], [http://pdbe.org/3ni9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ni9 RCSB], [http://www.ebi.ac.uk/pdbsum/3ni9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ni9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ni9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ni9 OCA], [https://pdbe.org/3ni9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ni9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ni9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ni9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAG2_PSEAI BLAG2_PSEAI] Extended-spectrum beta-lactamase (ESBL) which confers resistance to penicillins, as well as first, third and fourth-generation cephalosporins (PubMed:11502535, PubMed:19656947, PubMed:20696873, PubMed:21220532). Has modest carbapenem-hydrolyzing activity (PubMed:11502535, PubMed:19656947, PubMed:25485972). Has cefotaxime-hydrolyzing activity (PubMed:11502535, PubMed:19656947).<ref>PMID:11502535</ref> <ref>PMID:19656947</ref> <ref>PMID:20696873</ref> <ref>PMID:21220532</ref> <ref>PMID:25485972</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3ni9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3ni9" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Frase, H]]
[[Category: Large Structures]]
[[Category: Smith, C A]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Toth, M]]
[[Category: Frase H]]
[[Category: Vakulenko, S B]]
[[Category: Smith CA]]
[[Category: Antibiotic resistance]]
[[Category: Toth M]]
[[Category: Beta-lactamase]]
[[Category: Vakulenko SB]]
[[Category: Carbapenemase]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/3ni9"