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==Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli==
==Complex of C. elegans eIF4E-3 with the 4E-binding protein Mextli==
<StructureSection load='5aby' size='340' side='right' caption='[[5aby]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='5aby' size='340' side='right'caption='[[5aby]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5aby]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ABY FirstGlance]. <br>
<table><tr><td colspan='2'>[[5aby]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ABY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ABY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5abu|5abu]], [[5abv|5abv]], [[5abx|5abx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aby OCA], [http://pdbe.org/5aby PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aby RCSB], [http://www.ebi.ac.uk/pdbsum/5aby PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aby ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aby OCA], [https://pdbe.org/5aby PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aby RCSB], [https://www.ebi.ac.uk/pdbsum/5aby PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aby ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IF4E3_CAEEL IF4E3_CAEEL]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Ife-3 is essential for viability.<ref>PMID:10744754</ref> <ref>PMID:12422237</ref> <ref>PMID:9553113</ref>
[https://www.uniprot.org/uniprot/IF4E3_CAEEL IF4E3_CAEEL] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivity to mRNA caps. Ife-3 is essential for viability.<ref>PMID:10744754</ref> <ref>PMID:12422237</ref> <ref>PMID:9553113</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5aby" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5aby" style="background-color:#fffaf0;"></div>
==See Also==
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caenorhabditis elegans]]
[[Category: Peter, D]]
[[Category: Large Structures]]
[[Category: Weichenrieder, O]]
[[Category: Peter D]]
[[Category: 4e binding protein]]
[[Category: Weichenrieder O]]
[[Category: Cap binding protein]]
[[Category: Gene regulation]]
[[Category: Translation]]
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