Cryptochrome: Difference between revisions

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New page: <StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code 4i6g)' scene=''> == Function == Cryptochrome (Cry) is a flavoprotein ...
 
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<StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code [[4i6g]])' scene=''>
<StructureSection load='4i6g' size='340' side='right' caption='Mouse cryptochrome-1 complex with FAD (PDB code [[4i6g]])' scene=''>


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== Function ==
== Function ==


Cryptochrome (Cry) is a flavoprotein associated with the biological clock function.  In ''Drosophila melanogaster'' it is also involved in blue-light photoreception<ref>PMID:18399544</ref>.
'''Cryptochrome''' (Cry) is a flavoprotein associated with the biological clock function.  In ''Drosophila melanogaster'' it is also involved in blue-light photoreception<ref>PMID:18399544</ref>.
*'''Cryptochrome-1''' is a circadian clock repressor<ref>PMID:25961797</ref>.
*'''Cryptochrome-2''' is a blue light receptor involved in flowering induction<ref>PMID:10476075</ref>.
*'''Cryptochrome-4''' is magnetically sensitive and thus is involved in night migration of birds<ref>PMID:34163056</ref>.  For details see [[Cryptochrome 4]].
 
See also [[JMS/cryptochrome]] and [[Period circadian protein]].


== Disease ==
== Disease ==


The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>.
The absence of Cry resulting in the lack of functional clock system leads to elevated proinflammatory cytokine activation and thus to increase incidence of chronic diseases such as diabetes, obesity and also cancer<ref>PMID:22778400</ref>.
== Relevance ==
== Structural highlights ==


== 3D Structures of cryptochrome ==
[[Cryptochrome 3D structures]]


</StructureSection>
</StructureSection>
== 3D Structures of cryptochrome ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[4i6e]], [[4k0r]], [[5t5x]] – mCry-1 – mouse  <br />
[[4jzy]], [[4gu5]], [[4k03]] – Cry-1 + FAD – ''Drosophila melanogaster''  <br />
[[1u3c]] – AtCry-1 PHR domain + FAD - ''Arabidopsis thaliana''<br />
[[1u3d]] – AtCry-1 PHR domain + FAD + AMPPNP<br />
[[4ct0]] – mCry-1 + PER2  <br />
[[4i6g]] – mCry-2 + FAD  <br />
[[4u8h]] – mCry-2 + PER2  <br />
[[4mlp]] – mCry-2 + carbazol derivative  <br />
[[3zxs]] – Cry-2 + FAD – ''Rhodobacter sphaeroides'' <br />
[[2j4d]], [[2ijg]] – AtCry-3 + FAD <br />
[[2vtb]] – AtCry-3 + FAD + DNA<br />
[[3fy4]] – AtCry 6-4 + FAD <br />
[[1np7]] – Cry - ''Synechocystis''  <br />


== References ==
== References ==
Retrieved from "https://proteopedia.org/Cryptochrome"