6ezq: Difference between revisions

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New page: '''Unreleased structure''' The entry 6ezq is ON HOLD Authors: Wenskowsky, L., Liesum, A., Schreuder, H.A. Description: human Serum Albumin complexed with NBD-C12 fatty acid [[Category:...
 
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'''Unreleased structure'''


The entry 6ezq is ON HOLD
==human Serum Albumin complexed with NBD-C12 fatty acid==
<StructureSection load='6ezq' size='340' side='right'caption='[[6ezq]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6ezq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C7K:12-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]dodecanoic+acid'>C7K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ezq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ezq OCA], [https://pdbe.org/6ezq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ezq RCSB], [https://www.ebi.ac.uk/pdbsum/6ezq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ezq ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
== Function ==
[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A single high-affinity fatty acid binding site in the important human transport protein serum albumin (HSA) is identified and characterized using a NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-C12 fatty acid. This ligand exhibits a 1:1 binding stoichiometry in its HSA complex with high site-specificity. The complex dissociation constant is determined by titration experiments as well as radioactive equilibrium dialysis. Competition experiments with known HSA-binding drugs warfarin and ibuprofen confirm the new binding site to be different from Sudlow-sites I and II. These binding studies are extended to other albumin binders and fatty acid derivatives. Furthermore an X-ray crystal structure allows locating the binding site in HSA subdomain IIA. The knowledge about this novel HSA site will be important for drug depot development and for understanding drug-protein, which are important prerequisites for modulation of drug pharmacokinetics.


Authors: Wenskowsky, L., Liesum, A., Schreuder, H.A.
Identification and Characterization of a Single High-Affinity Fatty Acid Binding Site in Human Serum Albumin.,Petry S, Wenskowsky L, Schreuder H, Derdau V, Matter H, Volkmar J, Opatz T Angew Chem Int Ed Engl. 2017 Nov 28. doi: 10.1002/anie.201710437. PMID:29193545<ref>PMID:29193545</ref>


Description: human Serum Albumin complexed with NBD-C12 fatty acid
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Liesum, A]]
<div class="pdbe-citations 6ezq" style="background-color:#fffaf0;"></div>
[[Category: Wenskowsky, L]]
 
[[Category: Schreuder, H.A]]
==See Also==
*[[Albumin 3D structures|Albumin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liesum A]]
[[Category: Schreuder HA]]
[[Category: Wenskowsky L]]
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